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Article

Transmission dynamics of the M184V drug resistance mutation in primary HIV infection.

The Journal of antimicrobial chemotherapy - 1 Oct 2011

Wainberg Mark A, Moisi Daniela, Oliveira Maureen, Toni Thomas D'Aquin, Brenner Bluma G

Abstract excerpt

OBJECTIVES: M184V in HIV-1 reverse transcriptase is among the most common mutations in patients failing antiretroviral therapy but is found only rarely in cases of transmitted drug resistance. METHODS: To investigate this apparent paradox, we developed an allele-specific real-time PCR (AS-PCR) assay to determine the transmission of M184V in newly infected individuals. RESULTS: M184V transmission may occur to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21750100
DOI: 10.1093/jac/dkr291

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