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Article

Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations.

International journal of cancer - 15 Apr 2013

Tekpli Xavier, Landvik Nina E, Skaug Vidar, Gulsvik Amund, Haugen Aage, Zienolddiny Shanbeh

Abstract excerpt

Genome-wide association studies have demonstrated that genetic polymorphisms influence the risk of developing lung cancer. Nicotinic acetylcholine receptor alpha3, alpha5 and beta4 genes (CHRNA3, CHRNA5 and CHRNB4) cluster at the 15q25.1 lung cancer susceptibility locus. We genotyped 310 patients with non-small cell lung cancer and a control group of 348 cancer-free individuals for seven sequence variants located...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Chromosomes, Human, Pair 13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nerve Tissue Proteins

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Share to Receptors, Nicotinic

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Source

Identifiers

PMID: 23011884
DOI: 10.1002/ijc.27870

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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