Article
Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.
Oncogene - 11 Jul 2013
Scherf D B, Sarkisyan N, Jacobsson H, Claus R, Bermejo J L, Peil B, Gu L, Muley T, Meister M, Dienemann H, Plass C, Risch A
Abstract excerpt
Genome-wide association studies have highlighted three major lung cancer susceptibility regions at 15q25.1, 5p15.33 and 6p21.33. To gain insight into the possible mechanistic relevance of the genes in these regions, we investigated the regulation of candidate susceptibility gene expression by epigenetic alterations in healthy and lung tumor tissues. For genes up or downregulated in lung tumors, the influence of...
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