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Article

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

Nature genetics - 1 May 2008

Amos Christopher I, Wu Xifeng, Broderick Peter, Gorlov Ivan P, Gu Jian, Eisen Timothy, Dong Qiong, Zhang Qing, Gu Xiangjun, Vijayakrishnan Jayaram, Sullivan Kate, Matakidou Athena, Wang Yufei, Mills Gordon, Doheny Kimberly, Tsai Ya-Yu, Chen Wei Vivien, Shete Sanjay, Spitz Margaret R, Houlston Richard S

Abstract excerpt

To identify risk variants for lung cancer, we conducted a multistage genome-wide association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston, Texas. For replication, we evaluated the ten SNPs most significantly associated with lung cancer in an additional 711 cases...

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Source

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Identifiers

PMID: 18385676
DOI: 10.1038/ng.109
PMCID: PMC2713680

Genes

CHRNA3
CHRNA5
PSMA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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