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Article

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability.

Annals of neurology - 1 Dec 2009

Estacion Mark, Harty T Patrick, Choi Jin-Sung, Tyrrell Lynda, Dib-Hajj Sulayman D, Waxman Stephen G

Abstract excerpt

Sodium channel Na(V)1.7, encoded by the SCN9A gene, is preferentially expressed in nociceptive primary sensory neurons, where it amplifies small depolarizations. In studies on a family with inherited erythromelalgia associated with Na(V)1.7 gain-of-function mutation A863P, we identified a nonsynonymous single-nucleotide polymorphism within SCN9A in the affected proband and several unaffected family members; this...

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PMID: 20033988
DOI: 10.1002/ana.21895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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