Article
No mutations in the voltage-gated NaV1.7 sodium channel alpha1 subunit gene SCN9A in familial complex regional pain syndrome.
European journal of neurology - 1 Jun 2010
de Rooij A M, Gosso M F, Alsina-Sanchis E, Marinus J, van Hilten J J, van den Maagdenberg A M J M
Abstract excerpt
BACKGROUND: Mutations in the voltage-gated Na(V)1.7 Na(+) channel alpha1 gene SCN9A have been linked to pain disorders, such as inherited primary erythromelalgia and paroxysmal extreme pain disorder. Both show clinical overlap with complex regional pain syndrome (CRPS), a condition that is charac...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Complex Regional Pain Syndromes
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Mutation
- NAV1.7 Voltage-Gated Sodium Channel
- Pedigree
- Polymerase Chain Reaction
- Sodium Channels
- Young Adult