Article
No mutations in the voltage-gated NaV1.7 sodium channel alpha1 subunit gene SCN9A in familial complex regional pain syndrome.
European journal of neurology - 1 Jun 2010
de Rooij A M, Gosso M F, Alsina-Sanchis E, Marinus J, van Hilten J J, van den Maagdenberg A M J M
Abstract excerpt
BACKGROUND: Mutations in the voltage-gated Na(V)1.7 Na(+) channel alpha1 gene SCN9A have been linked to pain disorders, such as inherited primary erythromelalgia and paroxysmal extreme pain disorder. Both show clinical overlap with complex regional pain syndrome (CRPS), a condition that is characterized by pain in association with combinations of vasomotor, sudomotor, sensory, and motor disturbances. Therefore,...
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