Article

Carriers of<i>SCN9A</i>variants linked to inherited and acquired pain syndromes show no alteration in the prevalence of pain or analgesic usage in the UK Biobank cohort

2025-03-13

Abstract excerpt

The voltage-gated sodium channel NaV1.7, encoded by the SCN9A gene, is integral to nociceptor excitability and pain sensation. Multiple gain-of-function SCN9A variants have been reported to cause autosomal dominant painful channelopathies, including primary erythromelalgia and paroxysmal extreme pain disorder, and they have been linked to the pathogenesis of painful small fibre neuropathies. The prevalence and imp...

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Literature Corpus work: f3169f39-67e0-51cc-ab1b-2aadedcdd78c
DOI: 10.1101/2025.03.12.25323817

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