Article
An investigation of Japanese subjects maps susceptibility to type 1 (insulin-dependent) diabetes mellitus close to the DQA1 gene.
Human immunology - 1 Jan 1992
Jacobs K H, Jenkins D, Mijovic C, Penny M, Uchigata Y, Cavan D, Hirata Y, Otani T, Fletcher J, Barnett A H
Abstract excerpt
Insulin-dependent diabetic and control subjects of Japanese origin were HLA-DRB1, -DQB1, and -DQA1 typed using restriction fragment length polymorphism analysis and sequence-specific oligonucleotide gene probing. The DQA1 allele DQA1*0301 was positively associated with the disease [48/52 (92%) diabetic patients versus 44/64 (69%) control subjects, Pc less than 0.03, RR = 4.97]. Alleles of the DRB1 and DQB1 genes...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Gene Frequency
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Humans