Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus.

doi:10.1210/jcem.75.5.1358911

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Article

Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus.

The Journal of clinical endocrinology and metabolism - 1 Nov 1992

Ikegami H, Kawaguchi Y, Yamato E, Kuwata S, Tokunaga K, Noma Y, Shima K, Ogihara T

Abstract excerpt

DNA sequence analysis of class II HLA from Caucasian and black patients with type 1 (insulin-dependent) diabetes mellitus has suggested that aspartic acid at position 57 (Asp 57) of the DQ beta chain provides protection against insulin-dependent diabetes mellitus (IDDM). In contrast, most Japanes...

Topics

Adult
Aging
Alleles
Asian People
Base Sequence
Diabetes Mellitus, Type 1
Genes
Genetic Predisposition to Disease
HLA Antigens
HLA-DQ Antigens
HLA-DR Antigens
HLA-DR Serological Subtypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Japan

Molecular Probes

Molecular Sequence Data

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1358911
DOI: 10.1210/jcem.75.5.1358911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1358911-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus.PMID 1358911Read ↗

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

Aspartic acid at position 57 of the HLA-DQ beta chain in insulin-dependent diabetes mellitus: an association with one DRw9-DQw9 subtype in the Chinese population.Semantic proximity Read ↗

The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.Semantic proximity Read ↗

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Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The role of genetic predisposition to type I (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

[Analysis of HLA-DR, -DQA1, -DQB1 genes in Japanese IDDM patients].Semantic proximity Read ↗

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.Semantic proximity Read ↗

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