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Article

Cis- and trans-eQTL TWASs of breast and ovarian cancer identify more than 100 susceptibility genes in the BCAC and OCAC consortia.

American journal of human genetics - 6 Jun 2024

Head S Taylor, Dezem Felipe, Todor Andrei, Yang Jingjing, Plummer Jasmine, Gayther Simon, Kar Siddhartha, Schildkraut Joellen, Epstein Michael P

Abstract excerpt

Transcriptome-wide association studies (TWASs) have investigated the role of genetically regulated transcriptional activity in the etiologies of breast and ovarian cancer. However, methods performed to date have focused on the regulatory effects of risk-associated SNPs thought to act in cis on a nearby target gene. With growing evidence for distal (trans) regulatory effects of variants on gene expression, we...

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Identifiers

PMID: 38723630
DOI: 10.1016/j.ajhg.2024.04.012
PMCID: PMC11179407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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