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Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1polymorphisms

12 Apr 2007

Abstract excerpt

BACKGROUND: Animal studies suggest that brain apolipoprotein E (apoE) levels influence amyloid-beta (Abeta) deposition and thus risk for Alzheimer's disease (AD). We have previously demonstrated that deletion of the ATP-binding cassette A1 transporter (ABCA1) in mice causes dramatic reductions in brain and cerebrospinal fluid (CSF) apoE levels and lipidation. To examine whether polymorphisms in ABCA1 affect CSF...

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PMID: 17430597
DOI: 10.1186/1750-1326-2-7

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