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Article

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins.

PloS one - 1 Jan 2016

Boehm-Cagan Anat, Bar Roni, Harats Dror, Shaish Aviv, Levkovitz Hana, Bielicki John K, Johansson Jan O, Michaelson Daniel M

Abstract excerpt

Apolipoprotein E4 (apoE4), the leading genetic risk factor for Alzheimer's disease (AD), is less lipidated compared to the most common and AD-benign allele, apoE3. We have recently shown that i.p. injections of the ATP-binding cassette A1 (ABCA1) agonist peptide CS-6253 to apoE mice reverse the hypolipidation of apoE4 and the associated brain pathology and behavioral deficits. While in the brain apoE is the main...

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Source

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Identifiers

PMID: 27824936
DOI: 10.1371/journal.pone.0166195
PMCID: PMC5100931

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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