Article
Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.
Science translational medicine - 19 Sept 2012
Henderson Christina, Wijetunge Lasani, Kinoshita Mika Nakamoto, Shumway Matthew, Hammond Rebecca S, Postma Friso R, Brynczka Christopher, Rush Roger, Thomas Alexia, Paylor Richard, Warren Stephen T, Vanderklish Peter W, Kind Peter C, Carpenter Randall L, Bear Mark F, Healy Aileen M
Abstract excerpt
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism, results from the transcriptional silencing of FMR1 and loss of the mRNA translational repressor protein fragile X mental retardation protein (FMRP). Patients with FXS exhibit changes in neuronal dendritic spine morphology, a pathology associated with altered synaptic function. Studies in the mouse model of fragile X...
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