Article

CB1 receptor inhibition in fragile X syndrome mice impacts alternative splicing alterations in hippocampal synaptoneurosomal transcriptome

2025-07-04

Abstract excerpt

<h4>Background</h4> Fragile X syndrome (FXS) conveys the most frequent heritable genetic cause of intellectual disability and autism. It is caused by a CGG repeat expansion in FMR1 gene that leads to the loss of fragile X messenger ribonucleoprotein 1 (FMRP). FMRP is highly abundant in synapses, where regulates mRNAs to maintain synaptic plasticity. Treatments under development significantly ameliorate neurologi...

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Literature Corpus work: 95555c93-2c15-5e61-8643-4c9ae5aa7cea
DOI: 10.1101/2025.07.01.662539

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