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Article

Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study.

Respiratory research - 19 Sept 2012

Wallace Alison M, Mercer Becky A, He Jianqing, Foronjy Robert F, Accili Domenico, Sandford Andrew J, Paré Peter D, D'Armiento Jeanine M

Abstract excerpt

BACKGROUND: Prior studies have demonstrated that the distal 1.5 kb of the MMP-1 promoter is fundamental in directing the induction of the MMP-1 gene by cigarette smoke. METHODS: To characterize the genetic variants in the MMP-1 cigarette smoke-responsive element, deep re-sequencing of this element was performed on DNA samples from participants in the Lung Health Study. Furthermore, evidence of Sp1 binding to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22992122
DOI: 10.1186/1465-9921-13-79
PMCID: PMC3509005

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