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Identification of a Cigarette Smoke–Responsive Region in the Distal MMP-1 Promoter

10 Jul 2008

Abstract excerpt

Tobacco-related diseases are leading causes of death worldwide, and many are associated with expression of matrix metalloproteinase-1 (MMP-1). We have reported extracellular signal-regulated kinase (ERK)1/2-dependent induction of MMP-1 by cigarette smoke in lung epithelial cells. Our objectives were to define regions of the human MMP-1 promoter required for activation by smoke, to identify differences in...

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PMID: 18617682
DOI: 10.1165/rcmb.2007-0310oc

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