Article
Modification of gene expression of the small airway epithelium in response to cigarette smoking.
Journal of molecular medicine (Berlin, Germany) - 1 Jan 2007
Harvey Ben-Gary, Heguy Adriana, Leopold Philip L, Carolan Brendan J, Ferris Barbara, Crystal Ronald G
Abstract excerpt
The earliest morphologic evidence of changes in the airways associated with chronic cigarette smoking is in the small airways. To help understand how smoking modifies small airway structure and function, we developed a strategy using fiberoptic bronchoscopy and brushing to sample the human small airway (10th-12th order) bronchial epithelium to assess gene expression (Affymetrix HG-U133A and HG-133 Plus 2.0 array)...
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