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Article

Biologic phenotyping of the human small airway epithelial response to cigarette smoking.

PloS one - 1 Jan 2011

Tilley Ann E, O'Connor Timothy P, Hackett Neil R, Strulovici-Barel Yael, Salit Jacqueline, Amoroso Nancy, Zhou Xi Kathy, Raman Tina, Omberg Larsson, Clark Andrew, Mezey Jason, Crystal Ronald G

Abstract excerpt

BACKGROUND: The first changes associated with smoking are in the small airway epithelium (SAE). Given that smoking alters SAE gene expression, but only a fraction of smokers develop chronic obstructive pulmonary disease (COPD), we hypothesized that assessment of SAE genome-wide gene expression would permit biologic phenotyping of the smoking response, and that a subset of healthy smokers would have a "COPD-like"...

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Identifiers

PMID: 21829517
DOI: 10.1371/journal.pone.0022798
PMCID: PMC3145669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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