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Article

Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression.

Human molecular genetics - 1 Dec 2013

Buro-Auriemma Lauren J, Salit Jacqueline, Hackett Neil R, Walters Matthew S, Strulovici-Barel Yael, Staudt Michelle R, Fuller Jennifer, Mahmoud Mai, Stevenson Christopher S, Hilton Holly, Ho Melisa W Y, Crystal Ronald G

Abstract excerpt

The small airway epithelium (SAE), the first site of smoking-induced lung pathology, exhibits genome-wide changes in gene expression in response to cigarette smoking. Based on the increasing evidence that the epigenome can respond to external stimuli in a rapid manner, we assessed the SAE of smokers for genome-wide DNA methylation changes compared with nonsmokers, and whether changes in SAE DNA methylation were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23842454
DOI: 10.1093/hmg/ddt326
PMCID: PMC3888123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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