Article
New complexities of SOS-induced "untargeted" mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing.
DNA repair - 1 Jun 2020
Niccum Brittany A, Coplen Christopher P, Lee Heewook, Mohammed Ismail Wazim, Tang Haixu, Foster Patricia L
Abstract excerpt
When its DNA is damaged, Escherichia coli induces the SOS response, which consists of about 40 genes that encode activities to repair or tolerate the damage. Certain alleles of the major SOS-control genes, recA and lexA, cause constitutive expression of the response, resulting in an increase in spontaneous mutations. These mutations, historically called "untargeted", have been the subject of many previous...
Topics
- DNA, Bacterial
- DNA-Directed DNA Polymerase
- Escherichia coli
- Mutagenesis
- Mutation
- Mutation Rate
- SOS Response, Genetics
- Whole Genome Sequencing