Molecular mechanisms of cardiac voltage-gated potassium channelopathies.

Abstract excerpt

Potassium channels form highly K+ ion-selective pores in the plasma membrane of excitable cells. Voltage-gated potassium (Kv) channels open in response to membrane depolarization to allow rapid diffusion of K+ ions out of the cell, thus repolarizing the cell to restore a negative resting membrane potential. Inherited mutations in Kv channel genes produce abnormal cellular repolarization and cause diseases of...

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