In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment.

doi:10.1186/s12864-018-5010-5

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Article

In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment.

BMC genomics - 29 Aug 2018

Xu Yuhui, Liu Fei, Chen Suting, Wu Jiannan, Hu Yongfei, Zhu Baoli, Sun Zhaogang

Abstract excerpt

BACKGROUND: In the current scenario, the drug-resistant tuberculosis is a significant challenge in the control of tuberculosis worldwide. In order to investigate the in vivo evolution of drug-resistant M. tuberculosis, the present study envisaged sequencing of the draft genomes of 18 serial isolates from four pre-extensively drug-resistant (pre-XDR) tuberculosis patients for continuous genetic alterations....

Topics

Antitubercular Agents
Evolution, Molecular
Genotype
Humans
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis
Polymorphism, Single Nucleotide
Time Factors
Tuberculosis, Multidrug-Resistant

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Identifiers

PMID: 30157763
DOI: 10.1186/s12864-018-5010-5
PMCID: PMC6116439

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