Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells.

doi:10.1002/jcp.1041430323

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Article

Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells.

Journal of cellular physiology - 1 Jun 1990

Ishii K, Adachi Y, Hatanaka M, Sakamoto H, Furuyama J

Abstract excerpt

Cell hybrids (BIM) were produced between human neuroblastoma cells (IMR-32) and thymidine auxotrophs (B3T) of rat nerve-like cells (B103) in order to obtain cell lines undergoing stable neuronal differentiation. BIM cells exhibited the growth properties of partial transformation: 1) When the cell growth reached a plateau, BIM cells ceased to proliferate and expressed a differentiated phenotype. The shape of the...

Topics

1-Methyl-3-isobutylxanthine
Animals
Axons
Bucladesine
Calcimycin
Cell Cycle
Cell Transformation, Neoplastic
Colforsin
Cyclic AMP
Fibroblasts
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hybrid Cells

Methylcellulose

Neuroblastoma

Neurons

Phenotype

Rats

Thymidine

Source

Open in PubMed

Identifiers

PMID: 1694183
DOI: 10.1002/jcp.1041430323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1694183-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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