Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.

The Journal of biological chemistry - 9 Nov 2012

Aynaud Marie-Ming, Suspène Rodolphe, Vidalain Pierre-Olivier, Mussil Bianka, Guétard Denise, Tangy Frédéric, Wain-Hobson Simon, Vartanian Jean-Pierre

Abstract excerpt

The human polydeoxynucleotide cytidine deaminases APOBEC3A, APOBEC3C, and APOBEC3H are capable of mutating viral DNA in the nucleus, whereas APOBEC3A alone efficiently edits nuclear DNA. Deamination is rapidly followed by excision of uracil residues and can lead to double-stranded breaks. It is not known to which protein networks these DNA mutators belong. Using a yeast two-hybrid screen, we identified the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cytidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Deamination

Share to Microscopy, Confocal

Share to Proteasome Endopeptidase Complex

Share to Proto-Oncogene Proteins c-myc

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 22977230
DOI: 10.1074/jbc.M112.372722
PMCID: PMC3493958

Genes

TRIB3
ATM
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.PMID 22977230Read ↗

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integritySemantic proximity Read ↗

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.Semantic proximity Read ↗

APOBEC3 family proteins as drivers of virus evolutionSemantic proximity Read ↗

The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.Semantic proximity Read ↗

Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancerSemantic proximity Read ↗

Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and DeathSemantic proximity Read ↗

APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites.Semantic proximity Read ↗

APOBEC3A damages the cellular genome during DNA replicationSemantic proximity Read ↗

Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator.Semantic proximity Read ↗

The cytidine deaminase APOBEC3C has unique sequence and genome feature preferencesSemantic proximity Read ↗

The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences.Semantic proximity Read ↗

The AID/APOBEC family of nucleic acid mutatorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.