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Article

The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer.

Annals of surgical oncology - 1 Apr 2013

Takatsuno Yasushi, Mimori Koshi, Yamamoto Ken, Sato Tetsuya, Niida Atsushi, Inoue Hiroshi, Imoto Seiya, Kawano Shuhei, Yamaguchi Rui, Toh Hiroyuki, Iinuma Hisae, Ishimaru Shinya, Ishii Hideshi, Suzuki Sadao, Tokudome Shinkan, Watanabe Masahiko, Tanaka Jun-Ichi, Kudo Shin-Ei, Mochizuki Hidetaka, Kusunoki Masato, Yamada Kazutaka, Shimada Yasuhiro, Moriya Yoshihiro, Miyano Satoru, Sugihara Kenichi, Mori Masaki

Abstract excerpt

BACKGROUND: The oncogenic single nucleotide polymorphism rs6983267, located on 8q24.21, may affect copy number aberrations and/or expression profiles in colorectal cancer (CRC). We investigated the role of this single nucleotide polymorphism in the clinical outcome of CRC. METHODS: Array comparative genomic hybridization (aCGH) and oligomicroarrays were performed on cancer cells from 157 primary CRC tissues....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 8
Share to Comparative Genomic Hybridization
Share to Lymphatic Metastasis
Share to Neoplasm Recurrence, Local
Share to Peritoneal Neoplasms
Share to Proto-Oncogene Proteins c-myc
Share to Real-Time Polymerase Chain Reaction
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Source

Identifiers

PMID: 22976378
DOI: 10.1245/s10434-012-2657-z

Genes

MYC
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer.PMID 22976378Read ↗

Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer.Semantic proximity Read ↗

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.Semantic proximity Read ↗

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Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.Semantic proximity Read ↗

Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.Semantic proximity Read ↗

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.Semantic proximity Read ↗

Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer.Semantic proximity Read ↗

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