Article
Common genetic variants in the 9p21 region and their associations with multiple tumours.
British journal of cancer - 2 Apr 2013
Gu F, Pfeiffer R M, Bhattacharjee S, Han S S, Taylor P R, Berndt S, Yang H, Sigurdson A J, Toro J, Mirabello L, Greene M H, Freedman N D, Abnet C C, Dawsey S M, Hu N, Qiao Y-L, Ding T, Brenner A V, Garcia-Closas M, Hayes R, Brinton L A, Lissowska J, Wentzensen N, Kratz C, Moore L E, Ziegler R G, Chow W-H, Savage S A, Burdette L, Yeager M, Chanock S J, Chatterjee N, Tucker M A, Goldstein A M, Yang X R
Abstract excerpt
BACKGROUND: The chromosome 9p21.3 region has been implicated in the pathogenesis of multiple cancers. METHODS: We systematically examined up to 203 tagging SNPs of 22 genes on 9p21.3 (19.9-32.8 Mb) in eight case-control studies: thyroid cancer, endometrial cancer (EC), renal cell carcinoma, colorectal cancer (CRC), colorectal adenoma (CA), oesophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma...
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