Article
Uncovering networks from genome-wide association studies via circular genomic permutation.
G3 (Bethesda, Md.) - 1 Sept 2012
Cabrera Claudia P, Navarro Pau, Huffman Jennifer E, Wright Alan F, Hayward Caroline, Campbell Harry, Wilson James F, Rudan Igor, Hastie Nicholas D, Vitart Veronique, Haley Chris S
Abstract excerpt
Genome-wide association studies (GWAS) aim to detect single nucleotide polymorphisms (SNP) associated with trait variation. However, due to the large number of tests, standard analysis techniques impose highly stringent significance thresholds, leaving potentially associated SNPs undetected, and much of the trait genetic variation unexplained. Pathway- and network-based methodologies applied to GWAS aim to detect...
Topics
- Cardiomyopathies
- Computer Simulation
- Gene Regulatory Networks
- Genome, Human
- Genome-Wide Association Study
- Genomics
- Humans
- Internet
- Models, Genetic
- Molecular Sequence Annotation