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Article

A new permutation strategy of pathway-based approach for genome-wide association study.

BMC bioinformatics - 18 Dec 2009

Guo Yan-Fang, Li Jian, Chen Yuan, Zhang Li-Shu, Deng Hong-Wen

Abstract excerpt

BACKGROUND: Recently introduced pathway-based approach is promising and advantageous to improve the efficiency of analyzing genome-wide association scan (GWAS) data to identify disease variants by jointly considering variants of the genes that belong to the same biological pathway. However, the current available pathway-based approaches for analyzing GWAS have limited power and efficiency. RESULTS: We proposed a...

Topics

Algorithms
Computational Biology
Databases, Genetic
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20021635
DOI: 10.1186/1471-2105-10-429
PMCID: PMC2809078

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