Article

Association Study based on Topological Constraints of Protein-Protein Interaction Networks

2020-03-08

Abstract excerpt

The non-random interaction pattern of a protein-protein interaction network (PIN) is biologically informative but its potentials have not been fully utilized in omics studies. Here, we propose a network-permutation-based association study (NetPAS) method that gauges the observed interactions between two sets of genes based on the comparison between permutation null models and the empirical networks. This enables N...

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Literature Corpus work: 2485b2b2-dc0e-5ba3-b7c6-05f8b017099d
DOI: 10.1101/2020.03.06.981175

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