Article
Systematic permutation testing in GWAS pathway analyses: identification of genetic networks in dilated cardiomyopathy and ulcerative colitis.
BMC genomics - 22 Jul 2014
Backes Christina, Rühle Frank, Stoll Monika, Haas Jan, Frese Karen, Franke Andre, Lieb Wolfgang, Wichmann H-Erich, Weis Tanja, Kloos Wanda, Lenhof Hans-Peter, Meese Eckart, Katus Hugo, Meder Benjamin, Keller Andreas
Abstract excerpt
BACKGROUND: Genome wide association studies (GWAS) are applied to identify genetic loci, which are associated with complex traits and human diseases. Analogous to the evolution of gene expression analyses, pathway analyses have emerged as important tools to uncover functional networks of genome-wide association data. Usually, pathway analyses combine statistical methods with a priori available biological...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.