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Article

E2A-Pbx1, the t(1;19) Translocation Protein of Human Pre-B-Cell Acute Lymphocytic Leukemia, Causes Acute Myeloid Leukemia in Mice

1 Jan 1993

Abstract excerpt

One-quarter of pediatric pre-B-cell leukemias contain the t(1;19) chromosomal translocation, which fuses 5' exons encoding the transactivation domain of the E2A transcription factor gene to 3' exons ecoding the putative DNA-binding region of the unusual homeobox gene, PBX1. To test the leukemic potential of this fused gene, a cDNA encoding its major protein product, p85E2A-Pbx1, was incorporated into a retrovirus...

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Identifiers

PMID: 8093327
DOI: 10.1128/mcb.13.1.351-357.1993

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