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Article

Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A.

The Journal of biological chemistry - 27 Mar 2020

Lochhead Marina R, Brown Alexandra D, Kirlin Alyssa C, Chitayat Seth, Munro Kim, Findlay Jane E, Baillie George S, LeBrun David P, Langelaan David N, Smith Steven P

Abstract excerpt

The E-protein transcription factors guide immune cell differentiation, with E12 and E47 (hereafter called E2A) being essential for B-cell specification and maturation. E2A and the oncogenic chimera E2A-PBX1 contain three transactivation domains (ADs), with AD1 and AD2 having redundant, independent, and cooperative functions in a cell-dependent manner. AD1 and AD2 both mediate their functions by binding to the KIX...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E1A-Associated p300 Protein

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Source

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Identifiers

PMID: 32098872
DOI: 10.1074/jbc.RA119.011078
PMCID: PMC7105314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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