Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.

doi:10.1016/s1097-2765(03)00277-6

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Article

Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.

Molecular cell - 1 Aug 2003

Smith Kevin S, Chanda Sumit K, Lingbeek Merel, Ross Douglas T, Botstein David, van Lohuizen Maarten, Cleary Michael L

Abstract excerpt

Loss-of-function alterations of INK4A are commonly observed in lymphoid malignancies, but are consistently absent in pre-B cell leukemias induced by the chimeric oncoprotein E2a-Pbx1 created by t(1;19) chromosomal translocations. We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the INK4A-ARF tumor...

Topics

Apoptosis
Blotting, Western
Cell Line
Cell Transformation, Neoplastic
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16
Diploidy
Down-Regulation
Fibroblasts
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Genotype

Hematopoietic Stem Cells

Homeodomain Proteins

Humans

Nuclear Proteins

Oligonucleotide Array Sequence Analysis

Oncogene Proteins, Fusion

Source

Open in PubMed

Identifiers

PMID: 14536079
DOI: 10.1016/s1097-2765(03)00277-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14536079-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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