Article
The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non-AML myeloid neoplasms.
Genes, chromosomes & cancer - 1 Oct 2023
Kaseb Hatem, Visconte Valeria, Socha Daniel S, Crane Genevieve M, Durkin Lisa, Cook James R, Maciejewski Jaroslaw P, Hsi Eric D, Rogers Heesun J
Abstract excerpt
NPM1 mutated non-AML myeloid neoplasms (MN; <20% blasts) are characterized by an aggressive clinical course in a few studies. In this retrospective study, we evaluate the clinicopathologic and immunohistochemical features of non-AML MN patients with NPM1 mutations. We assessed NPM1 mutation by targeted next generation sequencing (NGS). Cytoplasmic NPM1 expression was assessed by immunohistochemistry (IHC) on...
Topics
Join the communities discussing this publication.