Article
Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2013
Radulescu Eugenia, Sambataro Fabio, Mattay Venkata S, Callicott Joseph H, Straub Richard E, Matsumoto Mitsuyuki, Weinberger Daniel R, Marenco Stefano
Abstract excerpt
Genetic variants in GPR85 (SREB2: rs56080411 and rs56039557) have been associated with risk for schizophrenia. Here, we test the hypothesis that these variants impact on brain function in normal subjects, measured with functional magnetic resonance imaging (fMRI) paradigms that target regions with greatest SREB2 expression (hippocampal formation and amygdaloid complex). During a facial emotion recognition...
Read the complete abstract on PubMed