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Article

Raloxifene increases prefrontal activity during emotional inhibition in schizophrenia based on estrogen receptor genotype.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2016

Kindler Jochen, Weickert Cynthia Shannon, Schofield Peter R, Lenroot Rhoshel, Weickert Thomas W

Abstract excerpt

People with schizophrenia show decreased prefrontal cortex (PFC) activity during emotional response inhibition, a cognitive process sensitive to hormonal influences. Raloxifene, a selective estrogen receptor modulator, binds estrogen receptor alpha (ESR-α), improves memory, attention and normalizes cortical and hippocampal activity during learning and emotional face recognition in schizophrenia. Here, we tested...

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Identifiers

PMID: 27842943
DOI: 10.1016/j.euroneuro.2016.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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