Article
The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2008
Matsumoto Mitsuyuki, Straub Richard E, Marenco Stefano, Nicodemus Kristin K, Matsumoto Shun-Ichiro, Fujikawa Akihiko, Miyoshi Sosuke, Shobo Miwako, Takahashi Shinji, Yarimizu Junko, Yuri Masatoshi, Hiramoto Masashi, Morita Shuji, Yokota Hiroyuki, Sasayama Takeshi, Terai Kazuhiro, Yoshino Masayasu, Miyake Akira, Callicott Joseph H, Egan Michael F, Meyer-Lindenberg Andreas, Kempf Lucas, Honea Robyn, Vakkalanka Radha Krishna, Takasaki Jun, Kamohara Masazumi, Soga Takatoshi, Hiyama Hideki, Ishii Hiroyuki, Matsuo Ayako, Nishimura Shintaro, Matsuoka Nobuya, Kobori Masato, Matsushime Hitoshi, Katoh Masao, Furuichi Kiyoshi, Weinberger Daniel R
Abstract excerpt
The G protein-coupled receptor (GPCR) family is highly diversified and involved in many forms of information processing. SREB2 (GPR85) is the most conserved GPCR throughout vertebrate evolution and is expressed abundantly in brain structures exhibiting high levels of plasticity, e.g., the hippoca...
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