Article
Preliminary study of structural magnetic resonance imaging phenotypes related to genetic variation in Interleukin-1β rs16944 in adolescents with Bipolar Disorder.
Journal of psychiatric research - 1 Mar 2020
Shonibare Daniel O, Patel Ronak, Islam Alvi H, Metcalfe Arron W S, Fiksenbaum Lisa, Kennedy James L, Freeman Natalie, MacIntosh Bradley J, Goldstein Benjamin I
Abstract excerpt
BACKGROUND: Bipolar disorder (BD), among the most heritable psychiatric conditions, is associated with increased pro-inflammatory blood markers and pro-inflammatory gene expression in post-mortem brain. We therefore examined the effects of pro-inflammatory single nucleotide polymorphism interleukin-1β (IL-1β) rs16944 on brain structure in adolescents with BD and healthy control (HC) adolescents. METHODS:...
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