Article
FKBP5 and attention bias for threat: associations with hippocampal function and shape.
JAMA psychiatry - 1 Apr 2013
Fani Negar, Gutman David, Tone Erin B, Almli Lynn, Mercer Kristina B, Davis Jennifer, Glover Ebony, Jovanovic Tanja, Bradley Bekh, Dinov Ivo D, Zamanyan Alen, Toga Arthur W, Binder Elisabeth B, Ressler Kerry J
Abstract excerpt
IMPORTANCE: The FKBP5 gene product regulates glucocorticoid receptor (GR) sensitivity and hypothalamic-pituitary-adrenal axis functioning and has been associated with many stress-related psychiatric disorders. The study of intermediate phenotypes, such as emotion-processing biases and their neural substrates, provides a way to clarify the mechanisms by which FKBP5 dysregulation mediates risk for psychiatric...
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