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New WS9326A Congeners from <i>Streptomyces</i> sp. 9078 Inhibiting <i>Brugia malayi</i> Asparaginyl-tRNA Synthetase

12 Sept 2012

Abstract excerpt

Lymphatic filariasis is caused by the Brugia malayi parasite. Three new congeners of the depsipeptide WS9326A (1), WS9326C (2), WS9326D (3), and WS9326E (4), were isolated from Streptomyces sp. 9078 by using a B. malayi asparaginyl-tRNA synthetase (BmAsnRS) inhibition assay. WS9326D specifically inhibits the BmAsnRS, kills the adult B. malayi parasite, and does not exhibit significant general cytotoxicity to...

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PMID: 22967068
DOI: 10.1021/ol302298k

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