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Actinoranone, a Cytotoxic Meroterpenoid of Unprecedented Structure from a Marine Adapted <i>Streptomyces</i> sp.

23 Oct 2013

Abstract excerpt

The isolation and structure elucidation of a new meroterpenoid, actinoranone (1), produced by a marine bacterium closely related to the genus Streptomyces is reported. Actinoranone is composed of an unprecedented dihydronaphthalenone polyketide linked to a bicyclic diterpenoid. The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data....

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PMID: 24152065
DOI: 10.1021/ol402080s

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