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The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in <i>P. falciparum</i> parasites

2019-11-01

Abstract excerpt

<h4>SUMMARY</h4> Salinipostin A (Sal A) is a potent antimalarial marine natural product with an undefined mechanism of action. Using a Sal A-derived activity-based probe, we identify its targets in the Plasmodium falciparum parasite. All of the identified proteins contain α/β serine hydrolase domains, and several are essential for parasite growth. One of the essential targets displays high homology to human mono...

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Literature Corpus work
062dde85-255f-5d22-a705-92bee1d81322
DOI
10.1101/827287
Open publication

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The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in <i>P. falciparum</i> parasitesDOI 10.1101/827287
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