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Positive allosteric modulation of emodepside sensitive <i>Brugia malayi</i> SLO-1F and <i>Onchocerca volvulus</i> SLO-1A potassium channels by GoSlo-SR-5-69

2025-02-05

Abstract excerpt

Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy against adult filarial worms. To expedite the elimination of both diseases, the introduction of drugs with adulticidal activity is paramount. The broad-spectrum anthelmintic emodepsi...

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Literature Corpus work
441cb21d-cc17-538e-a11e-963612beddf2
DOI
10.1101/2025.01.31.635861
Open publication

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Positive allosteric modulation of emodepside sensitive <i>Brugia malayi</i> SLO-1F and <i>Onchocerca volvulus</i> SLO-1A potassium channels by GoSlo-SR-5-69DOI 10.1101/2025.01.31.635861
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