Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.

Chemistry & biology - 1 Oct 2005

Seco Elena M, Fotso Serge, Laatsch Hartmut, Malpartida Francisco

Abstract excerpt

We recently characterized rimocidin B (3b) and CE-108B (4b) as two polyene amides with improved pharmacological properties, produced by genetically modified Streptomyces diastaticus var. 108. In this work, genetic and biochemical analysis of the producer strain show that the two amides are derived from the parental polyenes rimocidin (3a) and CE-108 (4a) by a post-PKS modification of the free side chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amides
Share to Macrolides
Share to Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Structure

Share to Monosaccharides

Share to Mutation

Share to Polyenes

Share to Streptomyces

Source

Identifiers

PMID: 16242652
DOI: 10.1016/j.chembiol.2005.08.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.PMID 16242652Read ↗

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strainSemantic proximity Read ↗

Identification and Predictions Regarding the Biosynthesis Pathway of Polyene Macrolides Produced by Streptomyces roseoflavus Men-myco-93-63Semantic proximity Read ↗

Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces nourseiSemantic proximity Read ↗

A Novel Peptide Antibiotic Produced by Streptomyces roseoflavus Strain INA-Ac-5812 With Directed Activity Against Gram-Positive BacteriaSemantic proximity Read ↗

Sequential improvement of rimocidin production in Streptomyces rimosus M527 by introduction of cumulative drug-resistance mutationsSemantic proximity Read ↗

Identification and Proposed Relative and Absolute Configurations of Niphimycins C–E from the Marine-Derived Streptomyces sp. IMB7-145 by Genomic AnalysisSemantic proximity Read ↗

Mining and manipulation of antibiotic biosynthesis in StreptomycesSemantic proximity Read ↗

Directed accumulation of less toxic pimaricin derivatives by improving the efficiency of a polyketide synthase dehydratase domain.Semantic proximity Read ↗

Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins.Semantic proximity Read ↗

Designed Biosynthesis of 36-Methyl-FK506 by Polyketide Precursor Pathway EngineeringSemantic proximity Read ↗

Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporusSemantic proximity Read ↗

Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR‐Cas9 ActivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.