A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.

doi:10.1016/j.chembiol.2005.08.007

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.

Chemistry & biology - 1 Oct 2005

Seco Elena M, Fotso Serge, Laatsch Hartmut, Malpartida Francisco

Abstract excerpt

We recently characterized rimocidin B (3b) and CE-108B (4b) as two polyene amides with improved pharmacological properties, produced by genetically modified Streptomyces diastaticus var. 108. In this work, genetic and biochemical analysis of the producer strain show that the two amides are derived from the parental polyenes rimocidin (3a) and CE-108 (4a) by a post-PKS modification of the free side chain...

Topics

Amides
Hemolytic Plaque Technique
Humans
Macrolides
Magnetic Resonance Spectroscopy
Molecular Structure
Monosaccharides
Mutation
Polyenes
Streptomyces

Source

Open in PubMed

Identifiers

PMID: 16242652
DOI: 10.1016/j.chembiol.2005.08.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics