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Article

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.

The Journal of biological chemistry - 26 Oct 2012

Varma Saaket, Cao Yuxia, Tagne Jean-Bosco, Lakshminarayanan Meenakshi, Li Jun, Friedman Thomas B, Morell Robert J, Warburton David, Kotton Darrell N, Ramirez Maria I

Abstract excerpt

The Grainyhead family of transcription factors controls morphogenesis and differentiation of epithelial cell layers in multicellular organisms by regulating cell junction- and proliferation-related genes. Grainyhead-like 2 (Grhl2) is expressed in developing mouse lung epithelium and is required for normal lung organogenesis. The specific epithelial cells expressing Grhl2 and the genes regulated by Grhl2 in normal...

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PMID: 22955271
DOI: 10.1074/jbc.M112.408401
PMCID: PMC3481326

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