Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion.

Journal of the American Society of Nephrology : JASN - 1 Nov 2015

Aue Annekatrin, Hinze Christian, Walentin Katharina, Ruffert Janett, Yurtdas Yesim, Werth Max, Chen Wei, Rabien Anja, Kilic Ergin, Schulzke Jörg-Dieter, Schumann Michael, Schmidt-Ott Kai M

Abstract excerpt

Grainyhead transcription factors control epithelial barriers, tissue morphogenesis, and differentiation, but their role in the kidney is poorly understood. Here, we report that nephric duct, ureteric bud, and collecting duct epithelia express high levels of grainyhead-like homolog 2 (Grhl2) and that nephric duct lumen expansion is defective in Grhl2-deficient mice. In collecting duct epithelial cells, Grhl2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Gene Transfer Techniques

Share to Histones

Share to Kidney

Share to Kidney Tubules, Collecting

Share to Oligonucleotide Array Sequence Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 25788534
DOI: 10.1681/ASN.2014080759
PMCID: PMC4625669

Genes

GRHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion.PMID 25788534Read ↗

Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epitheliumSemantic proximity Read ↗

Grainyhead-like (Grhl) Target Genes in Development and CancerSemantic proximity Read ↗

GRHL2-controlled gene expression networks in luminal breast cancerSemantic proximity Read ↗

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.Semantic proximity Read ↗

Genome-wide identification of binding sites of GRHL2 in luminal-like and basal A subtypes of breast cancerSemantic proximity Read ↗

Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studiesSemantic proximity Read ↗

A <i>Grhl2</i>-dependent gene network controls trophoblast branching morphogenesisSemantic proximity Read ↗

The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros developmentSemantic proximity Read ↗

Folliculin Deletion in the Mouse Kidney Results in Cystogenesis of the Loops of Henle via Aberrant TFEB ActivationSemantic proximity Read ↗

osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2Semantic proximity Read ↗

Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression.Semantic proximity Read ↗

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.