Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

doi:10.1073/pnas.87.23.9431

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Article

Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

Liebhaber S A, Griese E U, Weiss I, Cash F E, Ayyub H, Higgs D R, Horst J

Abstract excerpt

Synthesis of normal human hemoglobin A, alpha 2 beta 2, is based upon balanced expression of genes in the alpha-globin gene cluster on chromosome 16 and the beta-globin gene cluster on chromosome 11. Full levels of erythroid-specific activation of the beta-globin cluster depend on sequences located at a considerable distance 5' to the beta-globin gene, referred to as the locus-activating or dominant control...

Topics

Adult
Chromosome Deletion
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 16
Cloning, Molecular
DNA
Female
Gene Expression Regulation
Genes
Genotype
Globins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Multigene Family

RNA

Restriction Mapping

Reticulocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 1701260
DOI: 10.1073/pnas.87.23.9431
PMCID: PMC55179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1701260-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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