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Article

The PICALM protein plays a key role in iron homeostasis and cell proliferation.

PloS one - 1 Jan 2012

Scotland Paula B, Heath Jessica L, Conway Amanda E, Porter Natasha B, Armstrong Michael B, Walker Jennifer A, Klebig Mitchell L, Lavau Catherine P, Wechsler Daniel S

Abstract excerpt

The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM) protein associates with the plasma membrane, binds clathrin, and plays a role in clathrin-mediated endocytosis. Alterations of the human PICALM gene are present in aggressive hematopoietic malignancies, and genome-wide association studies have recently linked the PICALM locus to late-onset Alzheimer's disease. Inactivating and...

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Share to Clathrin
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endocytosis

Share to Intracellular Space

Share to Iron Chelating Agents

Share to Iron Deficiencies

Share to Monomeric Clathrin Assembly Proteins

Share to Receptors, Transferrin

Source

Open in PubMed Open full text

Identifiers

PMID: 22952941
DOI: 10.1371/journal.pone.0044252
PMCID: PMC3431333

Genes

PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The PICALM protein plays a key role in iron homeostasis and cell proliferation.PMID 22952941Read ↗

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.Semantic proximity Read ↗

PICALM and Alzheimer's Disease: An Update and Perspectives.Semantic proximity Read ↗

Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.Semantic proximity Read ↗

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.Semantic proximity Read ↗

The Role of PICALM in Alzheimer's Disease.Semantic proximity Read ↗

PICALM Genetic Variant Alters mRNA Expression Without Affecting Protein Levels or Tau Spreading in Alzheimer's Disease.Semantic proximity Read ↗

PICALM modulates autophagy activity and tau accumulationSemantic proximity Read ↗

Implication of a genetic variant at PICALM in Alzheimer’s disease patients and centenarians.Semantic proximity Read ↗

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