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Article

The PICALM protein plays a key role in iron homeostasis and cell proliferation.

PloS one - 1 Jan 2012

Scotland Paula B, Heath Jessica L, Conway Amanda E, Porter Natasha B, Armstrong Michael B, Walker Jennifer A, Klebig Mitchell L, Lavau Catherine P, Wechsler Daniel S

Abstract excerpt

The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM) protein associates with the plasma membrane, binds clathrin, and plays a role in clathrin-mediated endocytosis. Alterations of the human PICALM gene are present in aggressive hematopoietic malignancies, and genome-...

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Topics

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Share to Clathrin
Share to Embryo, Mammalian
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Space

Share to Iron Chelating Agents

Share to Iron Deficiencies

Share to Monomeric Clathrin Assembly Proteins

Share to Receptors, Transferrin

Source

Open in PubMed Open full text

Identifiers

PMID: 22952941
DOI: 10.1371/journal.pone.0044252
PMCID: PMC3431333

Genes

PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22952941-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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The PICALM protein plays a key role in iron homeostasis and cell proliferation.PMID 22952941Read ↗

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Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.Semantic proximity Read ↗

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.Semantic proximity Read ↗

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