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Article

PICALM modulates autophagy activity and tau accumulation

22 Sept 2014

Abstract excerpt

Genome-wide association studies have identified several loci associated with Alzheimer's disease (AD), including proteins involved in endocytic trafficking such as PICALM/CALM (phosphatidylinositol binding clathrin assembly protein). It is unclear how these loci may contribute to AD pathology. Here we show that CALM modulates autophagy and alters clearance of tau, a protein which is a known autophagy substrate...

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PMID: 25241929
DOI: 10.1038/ncomms5998

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