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Article

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.

PloS one - 1 Jan 2012

Suzuki Mai, Tanaka Hirokazu, Tanimura Akira, Tanabe Kenji, Oe Natsuko, Rai Shinya, Kon Syunsuke, Fukumoto Manabu, Takei Kohji, Abe Takaya, Matsumura Itaru, Kanakura Yuzuru, Watanabe Toshio

Abstract excerpt

Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal translocation t(10;11)(p13;q14). CALM is sufficient to drive...

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Source

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Identifiers

PMID: 22363754
DOI: 10.1371/journal.pone.0031854
PMCID: PMC3283694

Genes

PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22363754-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.PMID 22363754Read ↗

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.Semantic proximity Read ↗

The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.Semantic proximity Read ↗

The PICALM protein plays a key role in iron homeostasis and cell proliferation.Semantic proximity Read ↗

A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly.Semantic proximity Read ↗

Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.Semantic proximity Read ↗

Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.Semantic proximity Read ↗

Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cellsSemantic proximity Read ↗

Molecular mechanism and physiological functions of clathrin-mediated endocytosis.Semantic proximity Read ↗

PICALM modulates autophagy activity and tau accumulationSemantic proximity Read ↗

Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.Semantic proximity Read ↗

Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.Semantic proximity Read ↗

Cloning of the gene encoding the murine clathrin-associated adaptor medium chain mu 2: gene organization, alternative splicing and chromosomal assignment.Semantic proximity Read ↗

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